KEY BISCAYNE, Fla. (AP) -- The wind, the rain, the wrist, Greg Rusedski -- none of them seemed to bother Andre Agassi.

The bald one began his bid for a fifth Key Biscayne title Friday, overcoming inclement weather and Rusedski 6-3, 6-1 at the Nasdaq-100 Open.

Afterward, Agassi had ice on his right wrist, but that was just a precaution. He missed the Australian Open after hurting his wrist in January, and Nasdaq is just his fourth tournament this year.

The wrist is fine, Agassi said, and he may be poised for another Crandon Park title run.

``At this stage, I'm very eager,'' he said. ``I haven't played a whole lot of tennis in the last half a year.''

Even before Agassi played his opening match, Andy Roddick was out of the tournament, beaten by Juan Ignacio Chela 6-3, 2-6, 6-4.

``This year, I hadn't really had one of those days where I just didn't really play well and didn't show up,'' Roddick said. ``It was just one of those days. It's disappointing, but it happens sometimes, I guess.''

Roddick, the basher from nearby Boca Raton, had hoped to make another big splash in his backyard. Last year, he arrived at Key Biscayne ranked No. 119 and upset Pete Sampras in the third round.

This year, the ranking (12th), seeding (10th) and expectations were much higher for Roddick. But following a first-round bye, he struggled with his timing against Chela, sprayed 37 unforced errors and reached break point only twice.

``The court just seemed really small today,'' Roddick said with a rueful smile. ``Nothing was really clean the whole day.''

Eighth-seeded Serena Williams also won her opening match, but not without drawing jeers from the crowd. With American Lilia Osterloh serving two points from winning the first set at 5-4, 30-30, a light rain prompted Williams to ask chair umpire Anne Lasserre-Ullrich about halting play.

Osterloh wanted to continue, but Lasserre-Ullrich stopped the match for 5 minutes. Fans booed, and when play resumed and Williams won the next two points to even the set, they booed again.

``It was a little slick. Especially on the lines it was slick,'' Williams said. ``I just looked and asked the umpire what she thought.''

Gamesmanship by Williams? Osterloh didn't think so.

``It was the umpire's call,'' she said.

Williams won 7-5, 6-1. No. 3 Martina Hingis advanced more routinely, beating Janet Lee 6-1, 6-0.

Agassi, who has played just 12 matches this year, went six weeks without hitting a ball while his wrist healed.

``I was training the whole time, jumping out of my skin getting ready to play but not being able to,'' he said. ``Very frustrating.''

Agassi practiced for just eight days and returned at San Jose, where he reached the final before losing to top-ranked Lleyton Hewitt. He won the next week at Scottsdale, then was upset last week in the first round at Indian Wells by Michel Kratochvil.

That was his 10th match in 12 days.

``I was pretty beat up,'' he said. ``I needed just to rest and get ready so I'm healthy here.''

Agassi's game looked healthy against Rusedski. Despite a gusty wind and two rain delays, Agassi looked sharp from the baseline, chased down shots like a youngster and lived up to his reputation as the game's greatest service returner.

``He played very well,'' Rusedski said. ``He anticipates the ball very well. That's why he looks so quick. He reads a play probably a second faster than most people.''

That's been the case for years, which is how Agassi won the Key Biscayne title in 1990, 1995, 1996 and 2001. And he's off to a good start in 2002.