On Thursday, Hingis looks to move one step closer to the only Grand Slam title that has eluded her when she faces Catalina Castano of Colombia in a second-round match.

Capriati, the fourth seed and reigning Australian Open champion, meets Tathiana Garbin of Italy. Williams, seeded sixth, opposes Slovenian qualifier Katarina Srebotnik.

Three of the top five seeds on the men's side play their second-round matches, including Americans Andre Agassi and Pete Sampras.

Agassi, the third seed, goes against Frenchman Julien Boutter as he vies for his second French Open title in three years and second straight Grand Slam crown.

Sampras, who survived a five-set struggle with French qualifier Cedric Kauffmann in the first round, could have more problems with Spanish claycourt specialist Galo Blanco.

U.S. Open champion Marat Safin of Russia, seeded second, meets Alex Calatrava of Spain.

On Tuesday, Hingis looked determined to win her first title at Roland Garros as she dropped just one game in a victory over Spain's Gala Leon Garcia.

Hingis has emerged as the clear favorite after second seed Venus Williams and fifth seed Amelie Mauresmo made first-round exits, third seed Lindsay Davenport withdrew due to injury and seventh seed Elena Dementieva lost in the second round.

A winner of five Grand Slam titles, Hingis has come up short in French Open finals in 1997 and 1999.

Capriati was a straight-sets winner over Frenchwoman Emilie Loit in the first round as she guns for her second straight Grand Slam title.

In January, Capriati put a stamp on her comeback from personal problems as a teenager by defeating Monica Seles, Davenport and Hingis in consecutive matches to claim her first Grand Slam title. She also defeated Hingis in the final of the Family Circle Cup on clay.

Capriati became the youngest French Open semifinalist in 1990 at the age of 14.

Serena Williams, returning from a knee injury, avoided a similar fate as her sister Tuesday as she got past Sarah Pitkowski of France in three sets.

On Wednesday, the Williams sisters withdrew from doubles so that Serena could concentrate fully on singles.

Having arrived in Paris with just one victory on clay this season, Agassi swept past Sweden's Thomas Johansson in straight sets Tuesday to reach the second round. In January, he captured his seventh Grand Slam title with his triumph at Melbourne.

Sampras saved three match points in his first-round win over the unheralded Kauffmann, who has never won an ATP match. A winner of a record 13 Grand Slam titles, Sampras has never won the French Open.

On Wednesday, defending champion Gustavo Kuerten of Brazil and fourth seed Juan Carlos Ferrero of Spain cruised into the third round,

But it was teenage sensation Andy Roddick who stole the show as he overcame cramps to pull out a five-set win over fellow American and former champion Michael Chang.

On the women's side, seventh seed Elena Dementieva of Russia was dismissed by Slovakia's Henrieta Nagyova.